Proteostasis and Mitochondrial Pathways in the Pathogenesis and Treatment of Parkinson’s Disease

After receiving training in the roles of oxidative stress and dopamine neurochemistry in Parkinson’s disease, and the cell biology of gamma-secretase and Alzheimer’s disease Dr. LaVoie established an independent research program at Harvard Medical School and Brigham and Women’s Hospital in Boston focused on the earliest molecular events that underlie the pathogenesis of Parkinson’s disease. Using a wide array of in vitro and in vivo model systems, our current efforts center on intracellular trafficking and mitochondrial biology. In the summer of 2020, the lab will relocate to the University of Florida where Dr. LaVoie will become an Endowed Fixel Professor of Neurology and Co-Director of the Center for Translational Research in Neurodegeneration.