OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
The primary cilium is a cell surface organelle that has been described as a signaling hub because it concentrates a large number of specialized signaling components within its tiny volume. In particular, primary cilia sequester diverse GPCRs connected to cAMP signaling, such as receptors for dopamine (D1R), serotonin (5-HT6) and somatostatin (SSTR3). Interest in ciliary cAMP signaling has expanded greatly following the discovery that cAMP-dependent protein kinase A (PKA) is among the kinases regulating the ciliary transcription factors that mediate canonical Hedgehog (Hh) signaling (i.e. through phosphorylation of Gli transcription factors). This presentation will describe optical approaches for interrogating the cAMP signaling microdomain of the primary cilium. Our direct organelle measurements challenge some of the assumptions about the nature of cAMP signaling in the ciliary space and suggest possible roles for GPCRs in Hh regulation.
