OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Gain-of-function mutations in the gene encoding phosphodiesterase (PDE) 3A cause hypertension with brachydactyly (HTNB). If the hypertension is not treated, the patients die of stroke by the age of 50 years. Even treated, the blood pressure does not reach physiological levels. Surprisingly, despite the decade-long hypertension, HTNB patients do not show cardiac damage. The presentation comprises an introduction of HTNB and will show analyses of HTNB rat and cell-based models, which suggest mechanisms accounting for the cardioprotection of the mutations.
