The recent infected blood inquiry report has highlighted the importance of transfusion practice and thrown down the gauntlet for clinicians and researchers to drive improvements in this area. To do this the field requires both a thorough understanding of current clinical practice as well as clear patient specific guidelines to direct treatment, both accompanied by a robust means of assessing these at scale within the NHS. The NIHR funded Blood and Transplant Research Unit in Data Driven Transfusion practice is a collaborative research programme, bringing members of the public & patients together with researchers and clinicians, to improve transfusion care. Our work includes the development and analysis of a number of national transfusion datasets, the piloting of automated auditing and feedback mechanisms. Alongside this work health economic evaluations and the testing of embedded trials is being carried out to help create a truly ‘learning health system’ for future use. Come and hear about the challenges and successes of this diverse research programme as it enters its 3rd year and learn more about how routine patient data can drive improved clinical practice and outcomes for all.