OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Compulsive behavior is a hallmark of substance use disorder and other addictive disorders. My lab models compulsive behavior in mice using a reinforcement training paradigm (RI60) that leads to habitual and punishment-resistant reward-seeking. By using fiber photometry and optogenetics to measure and manipulate dopamine signals in vivo as compulsive behavior emerges, we are revealing how dopamine contributes to this addiction-relevant process. I will present published and unpublished work identifying the specific spatiotemporal features of dopamine signaling that drive compulsion, including evidence that adolescent stress – an important risk factor for addiction – reshapes key features of dopamine engagement in compulsion. These findings highlight the synaptic- and circuit-level mechanisms by which developmental experiences alter vulnerability to addiction and suggest new avenues for personalized treatment strategies.
