OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Crohn’s disease and ulcerative colitis are the two most common forms of inflammatory bowel disease (IBD). They are complex diseases characterised by severe gastrointestinal inflammation. Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with these disease. In this seminar I will present results from the latest GWAS and whole-exome sequencing studies of IBD, which have together identified hundreds of new susceptibility loci. I will also show how we have used single-cell RNA sequencing data from hundreds of samples to robustly identify genes differentially expressed between cases and controls, identify disease-relevant cell-types, map eQTLs at single cell-type resolution and nominate likely disease effector genes in a high-throughput manner. I will finish by describing two large longitudinal multiomic studies we are undertaking to identify biomarkers of drug response and disease progression.
