The nanoscale governance of TIGIT signalling and blockade

Jonathan is a Wellcome Trust Research Fellow based in the Lydia Becker Institute of Immunology and Inflammation and the Division of Immunology, Immunity to Infection & Respiratory Medicine. Jonathan is originally from South Wales and moved to London in 2006 for his undergraduate studies at Imperial College London, where he read Biology with a year in Europe and spent a year at the Université Paul Sabatier in Toulouse. In 2010, he then moved to the Institute of Cancer Research in London to complete a PhD with Dr. Claus Jørgensen working on oncogenic kinase signalling using mass spectrometry. For his postdoctoral studies, he switched fields to work in immunology firstly with Dr. Gloria Lopez-Castejon in 2015, working on the ubiquitination of the innate immune receptor NLRP3, and with Professor Dan Davis in 2018 where he used super-resolution microscopy to study the organisation of immunoreceptors. In 2024, he received a prestigious 8-year Wellcome Trust Career Development Award to establish his own research group at the University.