Dr. Colwell’s research focuses on the neural mechanisms underlying circadian rhythms and the consequences of their disruption in disorders of the nervous system. His work has significantly advanced understanding of how biological clocks regulate behavior, cognition, sleep, and cellular function. Using a diverse set of approaches—including electrophysiology, molecular biology, and behavioral analysis—his laboratory investigates how circadian disruptions contribute to neurodegenerative and neurodevelopmental conditions. With a strong translational focus, Dr. Colwell explores novel interventions such as time-restricted feeding and light therapy to mitigate circadian-related dysfunction. To date, he and his students and collaborators have authored more than 180 publications.

In addition to his research, Dr. Colwell has served in numerous leadership roles in academic governance within the University of California. He is also widely recognized for his teaching and mentorship, having trained the next generation of scientists in neuroscience, sleep, and circadian biology. Dr. Colwell presently serves as Associate Director for the Semel Institute for Neuroscience and Human Behavior at UCLA. The Semel Insitute is dedicated to the discovery of better treatments, prevention strategies, and cures for neuropsychiatric disorders. He is also the Chair of the Brain and Behavioral Health undergraduate program which is focused on training the next generation of mental health workers.