Abstract:

Normal ovarian function is crucial for the production of egg – essential for not only human fertility but animal fertility more generally. In the William’s group, we seek to increase scientific understanding of ovarian function and develop technologies to optimise the use of the ovary for human and endangered species fertility preservation. One key aspect in understanding the nutritional requirements of ovarian tissues and how the modern diet of ultra-processed foods affects this. Our programme of research is focused on human and rhino ovarian tissue but also utilises model species when required. Using multiple species has led to cross-species benefits as we have developed novel culture techniques that benefit all. These techniques are directed to develop mature eggs in vitro from primordial follicles in ovarian tissues. Freezing of tissues is also key to preserving function and we have now expanded our programme of research to incorporate cryobiology as one of our group’s key pillars. Our aim is to enhance and develop human and rhino follicles in culture, as well as preserve tissues and fertility for other endangered species. In line with our conservation agenda, we are also exploring novel ways of isolating cells from endangered species with the long-term aim of in vitro gametogenesis. With recent success in elephant, we are pushing ahead to expand this work to other species. In this seminar, all team members will share information about their projects and the work they are doing.