On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
Lymph nodes (LNs) function as filter for pathogens and are essential organs for initiating adaptive immunity. Lymphatic migration of myeloid cells to LNs is fundamental in this process as it informs on changes in the tissues. Here, we show that tissue-derived unconventional T cells (UTC) similarly migrate to draining LNs. Because each tissue harbors a distinct spectrum of UTC with specific differentiation states and TCR repertoires, every LN is populated by a distinctive tissue-determined mix of UTC. Functionally, UTC cooperate in interconnected units and shape immune responses that differ between LNs. These findings have potential implications for vaccination and immunotherapy.
