For our next talk, in the BDI/CHG (gen)omics Seminar series, we will be hearing from Xiaotong Wang, DPhil student, Department of Psychiatry, University of Oxford. We’re delighted to host Xiaotong in what promises to be a great talk!
Date: Tuesday 30 September
Time: 9:30 – 10:30
Talk title: Multi-Ancestry Conditional and Joint Analysis (Manc-COJO) applied to GWAS Summary Statistics
Location: BDI/OxPop seminar room 0
Bio
Xiaotong (Mark) Wang is a DPhil student at the Department of Psychiatry, supervised by Professors Naomi Wray and Peter Visscher. His research focuses on quantitative genetics, developing statistical methods to understand complex human traits and psychiatric disorders. He holds an Honors BSc in Statistics and Immunology from the University of Toronto and an MD from the University of Queensland. Motivated by clinical experience, he aims to bridge the gap between research and patient care.Research Interests:
Abstract
The conditional and joint (COJO) analysis of GWAS summary statistics to identify SNPs independently associated with a trait given a genomic correlation structure has become a standard post-GWAS analysis. GWAS meta-analyses are increasingly conducted across multiple ancestry groups and the validity of applying standard single ancestry COJO (Sanc-COJO) algorithm to the multi-ancestry context is unclear. We introduce Manc-COJO, a method for multi-ancestry conditional and joint analysis. Simulations and real-data analyses show that Manc-COJO improves the detection of independent signals and reduces false positives compared to Sanc-COJO (and ad hoc adaptations for multi-ancestry use). To identify ancestry-specific associations following application of Manc-COJO, we introduce Manc-COJO-MDISA as a follow-up algorithm to apply after Manc-COJO. The C++ software implementation of Manc-COJO improves on computational efficiency and memory usage for standard Sanc-COJO. It also allows input of linkage disequilibrium references either through direct calculation from individual-level genotype data (as in Sanc-COJO) or from pre-computed matrices, a useful option when the sharing individual data is restricted.
All members of the University are welcome to join, please let reception at BDI know you’re here for the seminar and sign-in. We hope you can join us!
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As a reminder, the (gen)omics seminar series runs every other Tuesday morning and is intended to increase interaction between individuals working in genomics across Oxford. We encourage in-person attendance where possible. There is time for discussion over, tea, coffee and pastries after the talks.
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