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Abstract: Avian Pathogenic Escherichia coli is a pathotype of E. coli which causes colibacillosis, a complex of extraintestinal diseases in birds. Colibacillosis is a big problem in the poultry industry, but despite a wealth of information available on APEC, we still cannot accurately predict which E. coli isolates will cause avian disease, as intestinal E. coli populations may contain APEC, and extraintestinally isolated E. coli may contain innocent bystanders, thus making it difficult to fulfil Koch’s postulates for most APEC. This presentation will focus on the use of genomics techniques to obtain a better understanding of APEC, what risks they may pose and where we can go next.
Reading List:
1) Collingwood C, Kemmett K, Williams N, Wigley P. Is the Concept of Avian Pathogenic Escherichia coli as a Single Pathotype Fundamentally Flawed? Front Vet Sci. 2014 Oct 14;1:5. doi: 10.3389/fvets.2014.00005. eCollection 2014. PMID: 26664913
2) Mageiros L, Méric G, Bayliss SC, Pensar J, Pascoe B, Mourkas E, Calland JK, Yahara K, Murray S, Wilkinson TS, Williams LK, Hitchings MD, Porter J, Kemmett K, Feil EJ, Jolley KA, Williams NJ, Corander J, Sheppard SK. Genome evolution and the emergence of pathogenicity in avian Escherichia coli. Nat Commun. 2021 Feb 3;12(1):765. doi: 10.1038/s41467-021-20988-w. PMID: 33536414
3) Mehat JW, van Vliet AHM, La Ragione RM. The Avian Pathogenic Escherichia coli (APEC) pathotype is comprised of multiple distinct, independent genotypes. Avian Pathol. 2021 Jul 9:1-15. doi: 10.1080/03079457.2021.1915960. Online ahead of print. PMID: 34047644
