Working at the intersection of politics, policy, industry, healthcare and academia, Professor Nick Watts will reflect on his time as Chief Sustainability Officer of the NHS, on the Lancet Commission on Sustainable Health Care, and his current role at the National University of Singapore. He will explore what net zero means in the context of health care, the influence of national (and transnational) politics, industry, and other stakeholder interests on advancing towards net zero across different geographical settings and unpack what works and what doesn’t. He will critically reflect on the role of innovation in reaching net zero and on what is needed to bring about change and to translate solutions into practice within the boundaries of what is politically, financially and technologically possible.