Cell shape formation controlled by cytoskeleton

Controlling cell shape is an essential function of all cells, which allows adjusting and adapting to various environments and requirements. Moreover, it is crucial for a number of cellular processes, particularly during cell polarization and migration. The synergistic action of several signaling pathways initiates changes of the cell shape and the outcome is seen as a remodeling of membrane- or cytoskeleton structures that provide a binding platform for various factors.

We are interested in elucidating mechanisms of cell shape formation and downstream cytoskeleton remodeling using cryo-EM together with biochemical and biophysical approaches.