OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Towards New Antibiotics – Targeting Penicillin Binding Proteins
The lecture will begin by giving some thoughts on possible reasons as to why β-lactams remain the most important antibacterials after more than 70 years of use. Mechanisms of resistance to the β-lactams will be described, focussing on the β-lactamases. A review of attempts to develop non β-lactams targeting the penicillin binding protein (PBP) targets of β-lactams and β-lactamases will be given. Work aimed at the development of single compounds targeting PBPs and both metallo and serine β-lactamases will be described.
