OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Cryo-EM single particle analysis is undergoing rapid changes. In this
talk, I will discuss how developments in sensitive and fast direct
electron detectors yield movies with relatively high signal-to-noise
ratios, and how new image processing techniques to deal with
beam-induced motions and structurally heterogeneous samples are now
yielding near-atomic resolution reconstructions for a wide range of
specimens. I will illustrate the potentials of these methods by
highlighting our recent results on various structures of human
gamma-secretase, the intramembrane protease complex responsible for
cleavage of amyloid precursor protein.
