Single cell metabolomics and targeted proteomic imaging of immune populations

Andrew Armitage is a Senior Postdoc in Prof. Hal Drakesmith’s group in the MRC TIDU at the MRC WIMM, working on interactions between iron deficiency and immunity.  He has a particular interest in understanding how iron deficiency and iron supplementation may affect immune development in infants from resource-limited. To this end, he has used mass cytometry to generate large immune profiling datasets from infant participants of an iron supplementation trial in Bangladesh, and is currently extending the methodology to enable single cell metabolic profiling of immune cells from infants.

Michalina Mazurczyk is Mass Cytometry Facility Manager in the MRC WIMM. She worked on multiple research projects applying flow cytometry by TOF in areas of immunology, immuno-oncology, haematology. She’s going to present the most recent project phenotyping bone marrow landscape in Chronic Myelomonocytic Leukaemia pre and post treatment. The project aimed to evaluate cell composition on diseased vs control conditions, presence and location of resident macrophages and characterise microenvironment surrounding HSPCs.