Schizophrenia as a disease of brain energy metabolism: The promise of therapeutic ketosis

Recent evidence suggest that there is a bioenergetics dysfunction characterized by abnormal glucose handling and mitochondrial deficit, in the brain of people with schizophrenia. We identified that ketogenic diet, which provides alternative fuel to glucose for bioenergetic processes in the brain, normalises schizophrenia-like behaviours in translationally relevant pharmacological, genetic and neurodevelopmental mouse models. We have obtained preliminary evidence that the ketogenic substance beta-hydroxybutyrate or faecal microbiota transfer from mice fed with ketogenic diet exert similar beneficial effects in mice maintained on standard diet. This talk will also provide some mechanistic insights on how ketogenic diet/ketosis may exert its therapeutic effect in schizophrenia.

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