OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
A high number of lymphocytes constitutively associate with epithelial tissues and these are called intraepithelial lymphocytes (IELs). IELs are not restricted to classical MHC and often express T cells receptors (TCRs). In this talk, I will discuss the capacity of TCR+ IELs in the skin to directly sense the health status of epithelial cells and to initiate a multifaceted response to promote homeostasis and tissue repair.
By a variety of means IELs cross-communicate with epithelial cells to regulate their proliferation, differentiation, transit time through the epidermis and even DNA repair. I will particularly focus on the importance of type 2 immunity in mediating immune-surveillance and will address how IL-33 contributes to skin homeostasis via regulation of tissue-resident Treg.
Overall, the talk will provide novel information on the versatile regulation of epithelial cells by type 2 immunity which ultimately strengthens the epithelial barrier and decreases susceptibility to damage and cancer development.
