Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
A high number of lymphocytes constitutively associate with epithelial tissues and these are called intraepithelial lymphocytes (IELs). IELs are not restricted to classical MHC and often express T cells receptors (TCRs). In this talk, I will discuss the capacity of TCR+ IELs in the skin to directly sense the health status of epithelial cells and to initiate a multifaceted response to promote homeostasis and tissue repair.
By a variety of means IELs cross-communicate with epithelial cells to regulate their proliferation, differentiation, transit time through the epidermis and even DNA repair. I will particularly focus on the importance of type 2 immunity in mediating immune-surveillance and will address how IL-33 contributes to skin homeostasis via regulation of tissue-resident Treg.
Overall, the talk will provide novel information on the versatile regulation of epithelial cells by type 2 immunity which ultimately strengthens the epithelial barrier and decreases susceptibility to damage and cancer development.
