OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Genome editing provides a mechanism to precisely change the DNA sequence of cells with single nucleotide precision. We have developed a highly efficient platform to modify multiple types of human stem cells, including hematopoietic stem cells and pluripotent stem cells, with high efficiency using a combination of CRISPR/Cas9 and AAV6. I will discuss our progress in applying this platform to several different genetic diseases of the blood and immune system including sickle cell disease and severe combined immunodeficiency. In addition, I will discuss our optimized protocols to generate precisely modified human pluritpotent stem cells.
