OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Actin filaments are polymers that interact with myosin motor
proteins and play important roles in cell motility, shape, and
development. Depending on its function, this dynamic network of
interacting proteins reshapes and organizes in a variety of structures,
including bundles, clusters, and contractile rings. Motivated by
observations from the reproductive system of the roundworm C. elegans,
we use an agent-based modeling framework to simulate interactions
between actin filaments and myosin motor proteins inside cells. We also
develop tools based on topological data analysis to understand
time-series data extracted from these filament network interactions. We
use these tools to compare the filament organization resulting from
myosin motors with different properties. We have also recently studied
how myosin motor regulation may regulate actin network architectures
during cell cycle progression. This work also raises questions about how
to assess the significance of topological features in common topological
summary visualizations.
