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Effective cancer immunotherapy requires identifying tumor-associated antigens and engineering T cells to recognize them precisely. I will discuss our recent development of complementary technologies: HLA-Shuttle, which reveals hidden antigens in immune-cold tumors; HLA3DB, a database of peptide conformational features; and TRACeR-I, a protein engineering platform for developing antigen-specific binding modules with programmable HLA restriction. Together, these tools address key bottlenecks in the antigen discovery-to-therapy pipeline
