On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
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As DNA is frequently subject to a wide array of molecularly distinct forms of damage, life has evolved various DNA repair mechanisms and associated processes, collectively termed the DNA-damage response (DDR). The importance of DNA repair and DDR mechanisms is underlined by their deregulation or loss causing cancer and various human genetic disorders whose pathologies include stem-cell exhaustion, developmental defects, infertility, immune-deficiency, neurodegeneration and/or premature ageing. Work in my laboratory aims to decipher DDR mechanisms, particularly those triggered by DNA double-strand breaks. In this talk, I will describe some of our recent work combining CRISPR-based genome engineering and genetic screens with mechanistic studies to identify new DDR factors/regulators and define their functions, and to define and understand cross talks and functional interactions between DDR components. I will also explain how our work has identified new avenues for anti-cancer therapy and is helping us understand how cancer cells can evolve resistance to therapeutic agents.