Oxford Events, the new replacement for OxTalks, will launch on 16th March. The two-week OxTalks freeze period starts on Monday 2nd March. During this time, there will be no facility to publish or edit events. The existing OxTalks site will remain available to view during this period. Once Oxford Events launches, you will need a Halo login to submit events. Full details are available on the Staff Gateway.
Metabolic inflammation in type-2 diabetes (T2D) is initiated by type-1 interferon signalling, through its transcriptional mediator IRF5. Whilst studies in auto-immunity link pro-inflammatory polarisation to increased glycolysis, this phenomenon remains unexplored in T2D or in the context of IRF5-dependent inflammation. We hypothesise that macrophage bioenergetic adaptation in T2D is distinct, due to the distinct nature of insult and systemic abundance of substrates. IRF5 may play a key role in adapting cellular bioenergetics to initiate, amplify and sustain inflammation. To address these hypotheses, we analysed public and in-house sequencing datasets and carried out mechanistic in vivo and ex vivo analyses.
