The National Institute for Health and Care Excellence is responsible for assessing most medicines launched in England, diagnostics, devices and digital products and creating clinical guidelines that identify the most clinically and cost-effective care. We’ll discuss how NICE assesses clinically and cost-effective care, including an interactive session where we work through different scenarios, such as a very expensive medicine for a few people and a very cheap medicine for many people. Finally, we’ll end with what kinds of innovations NICE are seeing now and anticipate in the near future, what they may mean for the health and care service, the practice of medicine and NICE assessment.