OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
I will discuss our work on the phagocyte NADPH oxdase (NOX2). This crucial multi-subunit complex generates reactive oxygen species (ROS) to kill pathogens but is also essential for immune regulation. We have described EROS as a crucial chaperone for NOX2 assembly and inflammasome signalling. I will present some published work and unpublished findings on EROS’s role in adaptive immunity and a novel regulator of reactive oxygen species generation. I will then describe how investigating the Duox2-Duoxa2 system in ROS generation led us to discover an essential role of thyroid hormone in NK cell biology. This is a collaboration with Alice Denton (Imperial College).
