OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Viruses developed various strategies to remodel infected cells to carry out genome replication and generate new progeny. While positive single-stranded RNA viruses hijack membranous organelles to form replication vesicles, many negative single-stranded RNA viruses use liquid organelles as a site of viral genome replication. We apply cellular cryo-electron tomography and correlative light and electron microscopy to study the replication and assembly of SARS-CoV-2 and Ebola viruses. We show that SARS-CoV-2 nsp3-4 are minimal components of the pore spanning double-membrane vesicles. In addition, we revealed Ebola virus nucleocapsid assembly inside membrane-less inclusion bodies using subtomogram averaging
