Oxford Events, the new replacement for OxTalks, will launch on 16th March. The two-week OxTalks freeze period starts on Monday 2nd March. During this time, there will be no facility to publish or edit events. The existing OxTalks site will remain available to view during this period. Once Oxford Events launches, you will need a Halo login to submit events. Full details are available on the Staff Gateway.
Viruses developed various strategies to remodel infected cells to carry out genome replication and generate new progeny. While positive single-stranded RNA viruses hijack membranous organelles to form replication vesicles, many negative single-stranded RNA viruses use liquid organelles as a site of viral genome replication. We apply cellular cryo-electron tomography and correlative light and electron microscopy to study the replication and assembly of SARS-CoV-2 and Ebola viruses. We show that SARS-CoV-2 nsp3-4 are minimal components of the pore spanning double-membrane vesicles. In addition, we revealed Ebola virus nucleocapsid assembly inside membrane-less inclusion bodies using subtomogram averaging
