OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Major Histocompatibility Complex (MHC molecules) are a cornerstone of the adaptive immune system. They present antigens to T-cells for surveillance.
While we have a reasonably large number of experimentally determined three-dimensional structures of MHC molecules, there is low diversity in the dataset and it represents a very small fraction of the universe of potential complexes.
Despite this caveat, we can discern patterns within antigen presentation/recognition in the bulk data. If we benchmark these methods robustly, we can potentially extend using synthetic data from machine learning prediction methods such as AlphaFold.
