Oxford Events, the new replacement for OxTalks, will launch on 16th March. The two-week OxTalks freeze period starts on Monday 2nd March. During this time, there will be no facility to publish or edit events. The existing OxTalks site will remain available to view during this period. Once Oxford Events launches, you will need a Halo login to submit events. Full details are available on the Staff Gateway.
We explore the structural mechanisms of brain function, with a focus on neuronal migration during cerebral cortex development and the role of the cytoskeleton. It highlights periventricular nodular heterotopia—a genetic disorder caused by mutations in filamin A—and introduces FILIP (filamin A interacting protein, FILIP1 for human), a molecule that degrades filamin A. Mutations in FILIP1 are linked to a spectrum of congenital disorders collectively termed FILIP1 disease. The study also presents new methods for visualizing neural circuits at the single-cell level, revealing early axonal targeting patterns that may inform future strategies for repairing disrupted neural networks. Unpublished findings and ongoing investigations into cytoskeletal regulation and neuropsychiatric implications are included.
