OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
We explore the structural mechanisms of brain function, with a focus on neuronal migration during cerebral cortex development and the role of the cytoskeleton. It highlights periventricular nodular heterotopia—a genetic disorder caused by mutations in filamin A—and introduces FILIP (filamin A interacting protein, FILIP1 for human), a molecule that degrades filamin A. Mutations in FILIP1 are linked to a spectrum of congenital disorders collectively termed FILIP1 disease. The study also presents new methods for visualizing neural circuits at the single-cell level, revealing early axonal targeting patterns that may inform future strategies for repairing disrupted neural networks. Unpublished findings and ongoing investigations into cytoskeletal regulation and neuropsychiatric implications are included.
