We explore the structural mechanisms of brain function, with a focus on neuronal migration during cerebral cortex development and the role of the cytoskeleton. It highlights periventricular nodular heterotopia—a genetic disorder caused by mutations in filamin A—and introduces FILIP (filamin A interacting protein, FILIP1 for human), a molecule that degrades filamin A. Mutations in FILIP1 are linked to a spectrum of congenital disorders collectively termed FILIP1 disease. The study also presents new methods for visualizing neural circuits at the single-cell level, revealing early axonal targeting patterns that may inform future strategies for repairing disrupted neural networks. Unpublished findings and ongoing investigations into cytoskeletal regulation and neuropsychiatric implications are included.