OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Chronic inflammation generates damage-associated molecular patterns (DAMPs) such as DNA that impact immune responses. DNA is sensed to activate the Stimulator of Interferon Genes (STING) adaptor which may stimulate or suppress immunity. In some cancer models DNA suppresses anti-tumour immunity to promote tumour growth by inducing indoleamine 2,3 dioxygenase (IDO). STING agonists enhance anti-tumour immunity but fail to control tumour growth unless immune checkpoints are also disrupted. DNA sensing pathways can also be exploited to attenuate autoimmunity in several models of clinical autoimmune syndromes. Hence, STING agonists can be used to manipulate immune balance in a range of chronic conditions.
