Influence of p53 on human immune and inflammatory responses in cancer and primary cells

Dr. Resnick’s work focuses on mechanisms of genome stability and on the function of the p53 regulatory network that signals stress and DNA chromosomal damage, using both yeast and human cells. Dr. Resnick’s Chromosome Stability Group has established new roles for p53 in immunity and inflammation, finding unique p53-NFkappaB interactions in human macrophages and showing that the innate immunity Toll-like receptor (TLR) gene family in primary human cells and many cancer lines responds to chromosome stressors, mostly via p53.