Deciphering the function of Cullin E3 Ligases in Diffuse Large B-Cell Lymphoma

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Luca is an Assistant Professor in Cancer Biology, Department of Cancer Biology, University of Pennsylvania.

The molecular mechanisms of cell proliferation and the field of Ubiquitin Proteasome System (UPS) have always been our main area of interest and fascination. We have the expertise, training and motivation necessary to study several different aspects of this incredibly broad field. Specifically, the training in mechanistic science, including molecular biology, biochemistry, cell/animal biology, has laid the groundwork to understand how ubiquitin ligases complexes monitor the molecular mechanisms in normal and malignant hematopoiesis. Our work has identified and studied multiple key factors regulating cellular pathways, such as DNA-damage checkpoints, cell cycle, circadian clock, Toll-like-Receptor and NF-κB activation, as documented in our publications. In addition, we have successfully collaborated with several scientists, and contributed to peer-reviewed publications from each of these projects.