Karuna Ganesh, MD, PhD, is a physician-scientist focused on investigating and treating metastatic gastrointestinal cancers at Memorial Sloan Kettering Cancer Center, New York, USA. She received her undergraduate and MD/PhD degrees from the University of Cambridge/MRC Laboratory of Molecular Biology, UK, where she studied mechanisms of antibody diversification with the late Professor Michael Neuberger. She trained in Internal Medicine at the Beth Israel Deaconess Medical Center/Harvard Medical School and in Medical Oncology at Memorial Sloan Kettering Cancer Center, where she completed a postdoctoral fellowship with Dr. Joan Massagué. Dr. Ganesh leads a research laboratory in the Molecular Pharmacology Program, is an Attending Physician in the Gastrointestinal Oncology Service, and Director of Metastasis Research in the Center for Colorectal Cancer at Memorial Sloan Kettering. The Ganesh lab studies molecular mechanisms of phenotypic plasticity and tumor:host co-evolution using patient samples, patient-derived and mouse models of metastatic cancer. The goal of the Ganesh lab is to identify crucial signaling nodes required for plasticity that can be therapeutically targeted to improve outcomes for patients with advanced cancer.