Cryo-EM structures illuminate binding sites and gating mechanisms in the pancreatic Katp channel.

Abstract: The pancreatic ATP-sensitive K+ channel (Katp) is a key regulator of insulin secretion due to its ability to couple the membrane potential to changes in intracellular glucose metabolism and is the receptor for the widely-used anti-diabetic sulfonylurea drugs. Greg, a PhD student with Prof. Show-Ling Shyng in Portland Oregon, has been using recent advances in cryo-EM to reveal near-atomic details of channel gating and regulation by sulfonylureas, while also confirming many of the in-depth functional experiments conducted over the last three decades.