OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Atherosclerotic cardiovascular disease (ASCVD) is a chronic inflammatory disease of the arterial walls characterized by accumulation of lipoproteins that are insufficiently cleared by phagocytes. Following the initiation of atherosclerosis, the pathological progression is accelerated by engagement of the adaptive immune system. Recently, several research groups reported that atherosclerosis triggers the breakdown of tolerance to self. This phenomenon was discovered by using single-cell RNA sequencing in conjunction with T cell receptor (TCR) sequencing. I will discuss the discovery papers, evaluate the supporting evidence, map out potential future work and discuss the clinical significance of this breakthrough. Rational approaches aimed at re-establishing immune tolerance may become game-changers in treating ASCVD and preventing its downstream sequelae including heart attacks and strokes.
