On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
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Immune-mediated diseases are among the strongest selective pressures driving human evolution. The major histocompatibility complex (MHC) locus that encodes human leukocyte antigen (HLA) proteins plays a vital role in our adaptive immune responses, and thus is crucial in understanding the human evolutionary process. Several non-competing natural selective regimes exist to explain how the MHC locus evolved, including balancing, and pathogen-driven positive and negative selection. However, owing to the complicated genomic structure of the MHC locus, it remains challenging to nominate specific genomic variations and haplotypes driving the observed selection signatures. In this talk, we will characterize HLA diversity among Gambian, China, Latino American and African American individuals. We will clarify selection dynamics that shaped the MHC locus in HLA selection signals.
