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Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 from 188 COVID-19 cases, including 43 samples at > 6 months post-infection. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics (Dan et al., Science 2021). I will also present a working model of the relationship between adaptive immune responses and COVID-19 disease.
