A characteristic feature of chronic inflammation is its predilection for certain anatomical sites. In this presentation, I will explore the concept of “Inflammation Location” to illustrate how unravelling the biological pathways underpinning the genetic, molecular, and cellular basis of inflammation across distinct yet clinically related Immune Mediated Inflammatory Diseases (IMIDs) can help explain why many some IMIDs are site specific and other systemic.
Traditional models of research in IMIDs silo their management within specific specialties and between children and adults. Patients with disease in one organ system often have co-morbid involvement of another organ and are treated in similar ways with similar drugs. Here I will provide a mechanistic link between gene-environment interactions and clinical outcomes via tissue biology. By breaking down the clinical and operational boundaries that prevent an integrated programme of experimental medicine research in IMIDs, we aim to deliver a tissue-based, cellular understanding of inflammation to facilitate cross-disease, cross-discipline, basket-trials which utilise Bayesian statistics to de-risk early-stage trials. In the longer term our aim is to link the cellular basis of IMIDs to therapeutic interventions that either target shared pathogenic mechanisms or are disease specific.

This seminar is hosted in-person at the Department of Psychiatry, Seminar Room. To join online, please use the details below:
zoom.us/j/94567124781?pwd=sVxXabbSWibdU8A9W2clQlG9neRGbQ.1

Meeting ID: 945 6712 4781
Passcode: 470970