OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Forces are important for tissues to grow, change shape and maintain integrity during complex but flawless developmental processes. My research has focused on understanding how forces influence cell behaviour during development, and recently I have been examining how forces influence growth control. This work has revealed that extracellular matrix (ECM) degradation is important for initiating growth in Drosophila histoblasts, a progenitor population that give rise to the adult abdomen. Furthermore, counter to the popular model of tissue tension promoting proliferation, ECM degradation leads to an increase in cell-cell junction tension whilst histoblasts undergo cell-cycle arrest. These results have led me to develop a micropatterned cell culture system to further probe the relationship between substrate dynamics and cell tension, and examine how forces travel through cells. This has revealed that in tissue culture, substrate dynamics also influence cell tension, with strong substrate attachment reducing cell-cell junction tension. This work suggests that ECM dynamics can control the flow of mechanical information across a tissue, but the consequences of this on mechanosensitive intracellular dynamics across a tissue needs further investigation.