OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Tumor progression has been shown to be correlated with the expression of tri- and tetra-antennary β1,6-N-acetylglucosamine-bearing N-glycans. Glioblastoma were reported to express highly variable amounts of both GnT-III and GnT-V mRNA suggesting an important physiological role in maintaining the balance of these exclusive enzymatic activities . We demonstrated that PST3.1a alters the β1,4-GlcNAc and β1,6-GlcNAc N-glycans of GBM stem cells (GBMSC), by inhibiting the GnT-V enzymatic activity and reducing GnT-III expression. In a second step physiological and signaling effects of PST3.1a were analyzed on GBMSC cultivated either in proliferation or differentiation culture media. In a third step the in vivo pharmacological activity was evaluated in a subcutaneous model using the SNB75 cell line and in orthotopic models using the GBMSC Gli4 and GliT. Finally we showed that mitochondrial gene expressions were negatively correlated with PsT3.1a cytotoxic activity against the NCI-60 cancer cell lines panel
