OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
T cell activation is governed by the interaction of the T cell receptor (TCR) with antigenic peptide:MHC (pMHC) that are found in the surface membranes of T cells and APCs. Protein interactions that occur between opposing cells are constrained to two dimensions (2D). To understand T cell activation and the process of antigen recognition, we have defined the 2D kinetics of affinity and bond lifetime that occurs under forces between TCR and pMHC. These data support that the 2D kinetics determines the fate of the T cell and provides potential mechanisms for regulating autoimmune disease and anti-tumor responses.
