OxTalks will soon be transitioning to Oxford Events (full details are available on the Staff Gateway). A two-week publishing freeze is expected in early Hilary to allow all events to be migrated to the new platform. During this period, you will not be able to submit or edit events on OxTalks. The exact freeze dates will be confirmed as soon as possible.
If you have any questions, please contact halo@digital.ox.ac.uk
T cell activation is governed by the interaction of the T cell receptor (TCR) with antigenic peptide:MHC (pMHC) that are found in the surface membranes of T cells and APCs. Protein interactions that occur between opposing cells are constrained to two dimensions (2D). To understand T cell activation and the process of antigen recognition, we have defined the 2D kinetics of affinity and bond lifetime that occurs under forces between TCR and pMHC. These data support that the 2D kinetics determines the fate of the T cell and provides potential mechanisms for regulating autoimmune disease and anti-tumor responses.
