OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Pharmacological MRI studies rely on the assumption that haemodynamic measures can be considered a proxy of altered neurotransmission. However, the fMRI signal has no intrinsic selectivity to any particular receptor sites and the degree to which haemodynamic response indexes the action at drug target sites is still an open question. To address this issue, we developed REACT (Receptor-Enriched Analysis of functional Connectivity by Targets), a multimodal method that enriches the resting state fMRI analysis with the molecular information about the distribution density of specific receptors in the brain. With this new approach, we are able to show that drug-induced functional effects can be understood through the distribution of their main targets.
