Targeting Endoplasmic Reticulum proteostasis in Cancer

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Eric Chevet is Research Director at the French National Institute for Health and Medical Research (Inserm). After a Ph.D. in Molecular Cell Biology from the University of Paris XI in 1996 during which he studied growth factor signalling, he moved to Montreal, Canada for a post-doctoral fellowship at McGill University under the supervision of John Bergeron to work on the links between signalling and protein quality control in the endoplasmic reticulum. After this, he established his own laboratory at McGill University in 2001 as an assistant professor, before going back to France in 2006. For the past 20 years he has been investigating the role of endoplasmic reticulum stress signalling and proteostasis control in cancer development. Early 2015, he moved to Rennes in the West part of France to head a Cancer Research Laboratory within the Comprehensive Cancer Centre Eugène Marquis (INSERM U1242). The main objective of this research centre is to characterize select stress signalling pathways (including ER stress, death receptors, DNA damage, metabolism, non-coding RNA) in various cancers and develop novel relevant therapeutics to impede cancer development. Eric joins Traffic as Co-Editor in 2021.