On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
The Akbar group has identified multiple novel mechanisms that induce immune decline during ageing. They discovered a new inhibitory protein complex in aged T cells that is regulated by sestrins, which can be blocked to enhance vaccine responsiveness in mice. In addition they showed that defective immunity to viruses in the skin of old humans arises from excessive inflammation, that could be reversed by treatment with an anti-inflammatory p38 MAPkinase inhibitor in vivo. This Showed unequivocally that immune decline can be reversed during ageing both at the cellular level and in respoinse to antigen challenge in vivo. This has considerable implications for strategies to enhance immunity after severe infections and vaccination that are reduced during ageing.
