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Stromal-derived Follicular Dendritic Cells (FDCs) are indispensable for the orchestration of germinal centers (GCs), the epicenter of B cell antibody maturation. Despite their pivotal role, the transcriptome of human FDCs remains an enigma. Leveraging single-cell RNA sequencing and microarray analyses, we present a comprehensive transcriptomic portrait of these elusive cells, validated through flow cytometry and microscopy. This has led to surprising insights and new study directions, which I will discuss. Perhaps there is more regulation in de GC than we thought.
