OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Recording cell–cell interactions in vivo and isolating live interacting cell partners for downstream analysis holds immense potential for understanding how the immune system engages with tumours. Application of LIPSTIC (Labelling Immune Partnerships by SorTagging Intercellular Contacts) in tumour-bearing models has revealed a previously uncharacterised subpopulation of dendritic cells (DCs). These DCs engage directly with T cells, display a distinct transcriptomic signature, and possess enhanced T cell priming capacity. Notably, this subset also shows heightened responsiveness to immune checkpoint blockade therapy, underscoring its critical role in shaping effective anti-tumour immunity. As tumour–immune interactions can also promote immunosuppression, ongoing work employs LIPSTIC to map the tumour–immune interactome, offering insights into immune evasion and guiding strategies to enhance anti-tumour responses.
