This talk will be about the links between

a) The development of a device-agnostic system for electronic fetal monitoring, including physiological models and algorithms, biostatistical analyses of large data sets, guidelines and modern tools for telemonitoring.

b) The extension to the general concept of mobile monitoring of human biosignals with wearables and the subsequent reduction to a waist-worn multi-sensor system and data platform (my focus is on www.actibelt.com).

c) The application of some of the methodology and technology to e-clinical trials, using real world & registry data for research & regulatory decision making by EMA/FDA. The focus will be on the use of wearables to derive “real world walking speed” as a new outcome measure for Multiple Sclerosis and related diseases.