Spatial Regulation Of Nutrient Response Pathways


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I studied for my PhD at Imperial College London, where I was working on the regulation of cell-cell adhesion by small GTPases. My work explored how nutrient starvation impacted the spatio-temporal activity of these proteins, an area which I have continued to focus on throughout my career. My postdoctoral work at Newcastle University and now, as a Wellcome-funded Research Fellow in the School of Biochemistry at University of Bristol, is focused on understanding the molecular cell biology of the nutrient-responsive mTORC1-autophagy axis. The pro-growth mTORC1 pathway and the degradative autophagy-lysosome pathway control the dynamic balance between biosynthesis, degradation and recycling to maintain cellular proteostasis and homeostasis. We are studying the mechanisms controlling the spatial regulation and activity of these processes and how rewiring of this equilibrium contributes to cellular senescence (a tumour suppressor mechanism of cell cycle arrest).