Indigenous populations around the world have historically experienced—and continue to experience—both social and economic marginalization, and as a result are at disproportionate risk during public health emergencies. This has led to significant inequities during the COVID-19 pandemic. Unfortunately, measures taken in response to the pandemic have in some instances also created or exacerbated inequities experienced by Indigenous populations. This webinar will explore ethical challenges experienced by Indigenous populations during the COVID-19 pandemic, how explicit and implicit ‘vulnerabilities’ are portrayed and experienced in this context, and the role that traditional knowledge and practices have played as a source of resiliency.