Spatial deconvolution of immune cellular infiltrate in COVID lungs using single cell imaging mass cytometry

Prof Ling-Pei Ho is Professor of Respiratory Immunology at University of Oxford and a Consultant in Respiratory Medicine, sub-specializing in interstitial lung diseases.
Her group studies the immune mechanisms underlying lung injury, progressive lung fibrosis and aberrant alveolar regeneration, with a disease-centric focus (idiopathic
pulmonary fibrosis and fibrotic sarcoidosis). During the COVID pandemic much of her work was pivoted to understanding the immune drivers of severe lung injury and testing of new therapeutics to
improve outcome from COVID pneumonitis. The talk will describe the application of single cell imaging mass cytometry for the lungs, development of spatial analytical methods, and uncovering of immune cell organisation in lungs from patients with severe COVID pneumonitis.